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Recommendations when to order or not order the test. May include related or preferred tests.
Acceptable test to evaluate for suspected celiac disease (CD) in IgA-deficient individuals. Use in conjunction with Deamidated Gliadin Peptide (DGP) Antibody, IgG (0051359) is recommended.
The preferred test to screen for CD is Celiac Disease Reflexive Cascade, Serum (3016817).
New York DOH Approval Status
Indicates whether a test has been approved by the New York State Department of Health.
This test is New York state approved.
Specimen Required
Patient PreparationInstructions patient must follow before/during specimen collection.
CollectSpecimen type to collect. May include collection media, tubes, kits, etc.
Serum separator tube (SST).
Specimen PreparationInstructions for specimen prep before/after collection and prior to transport.
Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)
Storage/Transport TemperaturePreferred temperatures for storage prior to and during shipping to ARUP. See Stability for additional info.
Refrigerated.
Unacceptable ConditionsCommon conditions under which a specimen will be rejected.
Contaminated, grossly hemolyzed, grossly icteric, or grossly lipemic
RemarksAdditional specimen collection, transport, or test submission information.
StabilityAcceptable times/temperatures for specimens. Times include storage and transport time to ARUP.
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 30 days
Expected turnaround time for a result, beginning when ARUP has received the specimen.
1-2 days
Reference Interval
Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Test Number
Components
Reference Interval
Tissue Transglutaminase Antibody,IgG
0.00 - 4.99 FLU
Interpretive Data
May include disease information, patient result explanation, recommendations, or details of testing.
In individuals with low or deficient IgA, testing for tissue transglutaminase (tTG) and deamidated gliadin (DGP) antibodies of the IgG isotype is performed. A positive tTG and/or DGP IgG antibody results indicate celiac disease, however, small intestinal biopsy is required to establish a diagnosis due to the lower accuracy of these markers, especially in patients without IgA deficiency.
In individuals who produce sufficient total IgA, the most sensitive and specific serologic test for celiac disease (CD) diagnosis is tissue transglutaminase (tTG) IgA. In individuals who are IgA deficient, tTG IgG and deamidated gliadin peptide (DGP) IgG antibody testing is recommended.
Reflexive panel testing is preferred to screen for CD.
All serologic tests used to diagnose CD should be performed while the patient is on a gluten-containing diet. Upon initiation of a gluten-free diet, antibody titers decline in treatment-responsive patients, and the time frame to normalize titers varies by case. If serology is negative and suspicion for CD remains strong, intestinal biopsy may still be warranted to establish a diagnosis.
Hotline History
History of test changes published on ARUP Hotlines for the last two years
The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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